LERCANIDIPINE HYDROCHLORIDE
Lercanidipine hydrochloride
CAS: 132866-11-6;100427-27-8
Molecular Formula: C36H42ClN3O6
LERCANIDIPINE HYDROCHLORIDE - Names and Identifiers
LERCANIDIPINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C36H42ClN3O6 |
| Molar Mass | 648.19 |
| Melting Point | 175-177°C |
| Boling Point | 712.5°C at 760 mmHg |
| Flash Point | 384.7°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 3.77E-20mmHg at 25°C |
| Appearance | powder |
| Color | yellow |
| Merck | 14,5446 |
| Storage Condition | 2-8°C |
| MDL | MFCD07773089 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ |
| In vitro study | The calcium-antagonistic activity of Lercanidipine in vitro is associated with a gradual blockade of calcium influx into smooth muscle cells through L-type calcium channels. Lercanidipine inhibits the formation of cellular cholesteryl esters. At clinically used doses, Lercanidipine inhibits macrophage function in atherosclerosis formation as well as plaque stability in vitro. |
| In vivo study | In a canine model of Renovascular hypertension chronically catheterized, lercanidipine reduced diastolic blood pressure in a dose-dependent manner (ED25=0.9 mg/kg p.o.). Long-term treatment with lercanidipine will permanently lower diastolic blood pressure, indicating an intolerance to the hypotensive effect. Lercanidipine has a significant antispasmodic/anticonvulsant effect, in mice, it does not affect their muscle coordination and autonomic activity. In clinical studies, lercanidipine has a 24-hour antihypertensive effect without a significant increase in heart rate. In most patients with hypertension, lercanidipine is effective, the probability of adverse reactions is relatively low. |
LERCANIDIPINE HYDROCHLORIDE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| Toxicity | LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi) |
LERCANIDIPINE HYDROCHLORIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.522 ml | 7.608 ml | 15.216 ml |
| 5 mM | 0.304 ml | 1.522 ml | 3.043 ml |
| 10 mM | 0.152 ml | 0.761 ml | 1.522 ml |
| 5 mM | 0.03 ml | 0.152 ml | 0.304 ml |
Last Update：2024-01-02 23:10:35
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